2026-09-20T02:33:03Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/528032022-01-13T07:54:29Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
David K. Gifford.
Rolfe, P. Alexander (Philip Alexander), 1979-
Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
2010-03-24T20:39:09Z
2010-03-24T20:39:09Z
2009
2009
http://hdl.handle.net/1721.1/52803
549290868
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 137-142).
A Ruler Array measures the distance between a set of microarray probes and a set of experimentally defined locations in a nucleic acid, offering new possibilities for locating and characterizing changes in the nucleic acid sequence. Despite the known relevance of genomic changes to pathogens, cancer, development, and evolution, many of these changes evade detection by existing high-throughput techniques. Since a microarray can interrogate thousands or millions of probes at once, Ruler Arrays can screen a small genome or part of a mammalian sized genome for insertions, deletions, and inversions in a single experiment.
by Philip Alexander Rolfe.
Ph.D.
142 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Electrical Engineering and Computer Science.
Ruler arrays detect genomic insertions and deletions
Thesis
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<Abstract>A Ruler Array measures the distance between a set of microarray probes and a set of experimentally defined locations in a nucleic acid, offering new possibilities for locating and characterizing changes in the nucleic acid sequence. Despite the known relevance of genomic changes to pathogens, cancer, development, and evolution, many of these changes evade detection by existing high-throughput techniques. Since a microarray can interrogate thousands or millions of probes at once, Ruler Arrays can screen a small genome or part of a mammalian sized genome for insertions, deletions, and inversions in a single experiment.</Abstract>
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