2026-09-20T17:14:58Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/579962022-01-13T07:54:21Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Timothy F. Jamison.
Lauer, Andrew M. (Andrew Michael)
Massachusetts Institute of Technology. Dept. of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2010-09-01T13:43:54Z
2010-09-01T13:43:54Z
2010
2010
http://hdl.handle.net/1721.1/57996
655319475
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Progress coupling of substrates, toward the total synthesis of amphidinolide B1 is described. The reductive 1,3-eynes and ketones was explored. It was found to work well with simple but failed to yield intermediates toward amphidinolide B1 [images] ... The coupling of 1,3-enyne and aldehyde fragments toward the synthesis of amphidinolides G3 and H4 is also described. The entire carbon skeleton of these natural products has been prepared from this coupling and a subsequent installation of a methyl group using an indium based reagent ... [images].
by Andrew M. Lauer
Ph.D.
241 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
Studies directed toward the synthesis of the B-type amphidinolide natural products using nickel-catalyzed reductive couplings of enynes and carbonyl compounds
Thesis
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Publication
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<Abstract>Progress coupling of substrates, toward the total synthesis of amphidinolide B1 is described. The reductive 1,3-eynes and ketones was explored. It was found to work well with simple but failed to yield intermediates toward amphidinolide B1 [images] ... The coupling of 1,3-enyne and aldehyde fragments toward the synthesis of amphidinolides G3 and H4 is also described. The entire carbon skeleton of these natural products has been prepared from this coupling and a subsequent installation of a methyl group using an indium based reagent ... [images].</Abstract>
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