2026-09-19T00:43:40Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/625062022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Brian Anthony.
Selvakumar, Sivesh
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2011-04-25T16:10:24Z
2011-04-25T16:10:24Z
2010
2010
http://hdl.handle.net/1721.1/62506
712601407
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. [81]-82).
Components for on-chip storage and delivery of liquid reagent are necessary for many commercial applications of lab-on-a-chip technology. One such system uses a 'blister pack' that is pushed by an actuator. Over the course of product development, Daktari Diagnostics had completed nominal design of a blister pack for their flow rate requirements. This work involved performing a thorough variation analysis of the blister pack to determine the critical sources of variation. For this purpose, the tool of variation simulation modeling (VSM) was used. A numerical model of the blister performance was developed and Monte Carlo simulations were conducted. The results showed that this fluid delivery technique is robust and the number of out-of-specification parts was less than 2%. The critical blister pack parameters that must be controlled were also determined and these can be used to improve process capability.
by Sivesh Selvakumar.
M.Eng.
82 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Manufacturing of Lab-On-a-Chip devices : variation analysis of liquid delivery using blister packs
Manufacturing of LOC devices : variation analysis of liquid delivery using blister packs
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="4b26dd21-1df5-4fc1-9635-8865410004d9">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Manufacturing of Lab-On-a-Chip devices : variation analysis of liquid delivery using blister packs</Title>
<Subtitle>Manufacturing of LOC devices : variation analysis of liquid delivery using blister packs</Subtitle>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2010</PublicationDate>
<Authors>
<Author>
<DisplayName>Selvakumar, Sivesh</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>Components for on-chip storage and delivery of liquid reagent are necessary for many commercial applications of lab-on-a-chip technology. One such system uses a 'blister pack' that is pushed by an actuator. Over the course of product development, Daktari Diagnostics had completed nominal design of a blister pack for their flow rate requirements. This work involved performing a thorough variation analysis of the blister pack to determine the critical sources of variation. For this purpose, the tool of variation simulation modeling (VSM) was used. A numerical model of the blister performance was developed and Monte Carlo simulations were conducted. The results showed that this fluid delivery technique is robust and the number of out-of-specification parts was less than 2%. The critical blister pack parameters that must be controlled were also determined and these can be used to improve process capability.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>