2026-09-19T05:26:55Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/627772022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Richard A. Young.
Frampton, Garrett M
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2011-05-09T15:33:59Z
2011-05-09T15:33:59Z
2011
2011
http://hdl.handle.net/1721.1/62777
719368430
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references.
In mammalian development, a single fertilized egg grows into a complex organism, comprised of organs and tissues made up of hundreds of different specialized cell types. All of these cells contain the same genome, but express distinct sets of genes and proteins, which give the cells their specialized functions. Understanding how this process occurs is one of the fundamental goals of biology. Research using new technology for high-resolution genome-wide location analysis and gene expression profiling has allowed characterization of the transcriptional regulatory circuitry of cells in unprecedented detail. From this research emerges an improved understanding of how these cells work, how they malfunction in disease, and several general principles. This thesis describes several studies designed to understand the transcriptional regulatory circuitry of three different medically important cell types; embryonic stem cells, regulatory T cells and MLL leukemia cells.
by Garrett M. Frampton.
Ph.D.
286 p. (chiefly col.)
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
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http://dspace.mit.edu/handle/1721.1/7582
Biology.
Genomic analysis of control of cell type
Thesis
application/pdf
Publication
unknown
unknown
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