2026-09-20T13:07:43Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/688322022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Alexander H. Slocum.
Correll, Eric Owen
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2012-01-30T16:53:47Z
2012-01-30T16:53:47Z
2010
2011
http://hdl.handle.net/1721.1/68832
772528592
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2011.
"February 2011." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 14).
Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses the design of a machine for the desiccation of a mixture of solvent and pharmaceutical compound. The goal of this project was to provide a small-scale, high throughput method of continuous pharmaceutical drug drying for Novartis-MIT Center for Continuous Manufacturing. Specifications included a product flow rate of 100 grams per hour and a final product form of flowable powder. Several machines were built and tested, with the final design being comprised of a convective drum dryer and a modular continuous vacuum dryer.
by Eric Owen Correll.
S.B.
18 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients
Thesis
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false
Publication
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<Abstract>Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses the design of a machine for the desiccation of a mixture of solvent and pharmaceutical compound. The goal of this project was to provide a small-scale, high throughput method of continuous pharmaceutical drug drying for Novartis-MIT Center for Continuous Manufacturing. Specifications included a product flow rate of 100 grams per hour and a final product form of flowable powder. Several machines were built and tested, with the final design being comprised of a convective drum dryer and a modular continuous vacuum dryer.</Abstract>
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