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James G. Fujimoto. Lu, Chen David Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science 2013-06-17T19:49:29Z 2013-06-17T19:49:29Z 2013 2013 http://hdl.handle.net/1721.1/79233 845310839 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2013. Cataloged from PDF version of thesis. Includes bibliographical references. Optical coherence tomography (OCT) is a non-contact, high resolution biomedical imaging technique that uses low coherence interferometry to generate cross-sectional images of tissue. OCT has become a standard tool in ophthalmology for imaging the retina to detect or monitor pathologies. Recent research advances in swept source lasers have allowed swept source OCT (SS-OCT) to have 5-50x faster imaging speeds when compared to SD-OCT commercial systems. This thesis describes the design of a handheld SS-OCT instrument to screen for retinal diseases. Many retinal diseases are asymptomatic in their early stages and remain undetected until they advance to cause irreversible vision loss. Early detection and treatment of these diseases can prevent permanent damage to the retina. While OCT has been proven effective at diagnosing retinal pathology, most commercial systems are bulky and table mounted, limiting their screening capabilities. The compact and easy to use handheld device can be used to quickly screen patients outside of the ophthalmology clinic in primary care, pediatrics applications, or in the field in developing countries. A custom motion registration algorithm corrects for the additional operator motion in the images. The wide scanning angle combined with the high imaging speeds used in SS-OCT allows screening of pathology with a single volumetric data set spanning the areas of interest on the retina. by Chen David Lu. S.M. 82 p. eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Electrical Engineering and Computer Science. High speed handheld instrument for ophthalmic optical coherence tomography Thesis application/pdf false Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="ae1ecbb3-a3c0-4137-a157-56ab9aa2fd60"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>High speed handheld instrument for ophthalmic optical coherence tomography</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2013</PublicationDate> <Authors> <Author> <DisplayName>Lu, Chen David</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Electrical Engineering and Computer Science.</Keyword> <Abstract>Optical coherence tomography (OCT) is a non-contact, high resolution biomedical imaging technique that uses low coherence interferometry to generate cross-sectional images of tissue. OCT has become a standard tool in ophthalmology for imaging the retina to detect or monitor pathologies. Recent research advances in swept source lasers have allowed swept source OCT (SS-OCT) to have 5-50x faster imaging speeds when compared to SD-OCT commercial systems. This thesis describes the design of a handheld SS-OCT instrument to screen for retinal diseases. Many retinal diseases are asymptomatic in their early stages and remain undetected until they advance to cause irreversible vision loss. Early detection and treatment of these diseases can prevent permanent damage to the retina. While OCT has been proven effective at diagnosing retinal pathology, most commercial systems are bulky and table mounted, limiting their screening capabilities. The compact and easy to use handheld device can be used to quickly screen patients outside of the ophthalmology clinic in primary care, pediatrics applications, or in the field in developing countries. A custom motion registration algorithm corrects for the additional operator motion in the images. The wide scanning angle combined with the high imaging speeds used in SS-OCT allows screening of pathology with a single volumetric data set spanning the areas of interest on the retina.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>