2026-09-18T21:06:57Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/792622022-01-13T07:54:07Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Alexander van Oudenaarden and Paul Wiggins.
Ross, Brian Christopher
Massachusetts Institute of Technology. Department of Physics.
Massachusetts Institute of Technology. Department of Physics
2013-06-17T19:51:31Z
2013-06-17T19:51:31Z
2012
2012
http://hdl.handle.net/1721.1/79262
846592515
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 99-112).
DNA conformation within cells has many important biological implications, but there are challenges both in modeling DNA due to the need for specialized techniques, and experimentally since tracing out in vivo conformations is currently impossible. This thesis contributes two computational projects to these efforts. The first project is a set of online and offline calculators of conformational statistics using a variety of published and unpublished methods, addressing the current lack of DNA model-building tools intended for general use. The second project is a reconstructive analysis that could enable in vivo mapping of DNA conformation at high resolution with current experimental technology.
by Brian Christopher Ross.
Ph.D.
112 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Physics.
Computational tools for modeling and measuring chromosome structure
Thesis
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Publication
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