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Jung-Hoon Chun. Slaughter, Ryan (Ryan R.) Massachusetts Institute of Technology. Department of Mechanical Engineering. Massachusetts Institute of Technology. Department of Mechanical Engineering 2013-09-24T19:45:12Z 2013-09-24T19:45:12Z 2013 2013 http://hdl.handle.net/1721.1/81136 858281394 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2013. Cataloged from PDF version of thesis. Includes bibliographical references (p. 51-53). In this thesis, a continuous rollforming process for the folding of thin-films was proposed and studied as a key step in the continuous manufacturing of pharmaceutical tablets. HPMC and PEG based polymeric thin-films were considered for this application. An experimental apparatus was designed and developed to test the folding of thin-films. The experimental apparatus was designed in a modular fashion to facilitate testing of various process parameters. Analysis was carried out for the folding operations, based on which two folding strategies were proposed - (i) without scoring and (ii) with scoring. The first strategy relies on elastic deformation of the thin-films, whereas the later depends on localized, plastic deformation caused by the scoring geometry. From the experiments on folding we identified three regimes of process operation namely: insufficient scoring, appropriate scoring, and excessive scoring. The implications of different levels of scoring were observed and understood carefully for the scoring and folding operation. Practical guidelines were developed for carrying out folding successfully and the scope of future work was discussed. by Ryan Slaughter. S.M. 53 p. eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Mechanical Engineering. The development of a thin-film rollforming process for pharmaceutical continuous manufacturing Thesis application/pdf Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="418dad00-661c-4677-bb0d-38a1cc26a78a"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>The development of a thin-film rollforming process for pharmaceutical continuous manufacturing</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2013</PublicationDate> <Authors> <Author> <DisplayName>Slaughter, Ryan (Ryan R.)</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Mechanical Engineering.</Keyword> <Abstract>In this thesis, a continuous rollforming process for the folding of thin-films was proposed and studied as a key step in the continuous manufacturing of pharmaceutical tablets. HPMC and PEG based polymeric thin-films were considered for this application. An experimental apparatus was designed and developed to test the folding of thin-films. The experimental apparatus was designed in a modular fashion to facilitate testing of various process parameters. Analysis was carried out for the folding operations, based on which two folding strategies were proposed - (i) without scoring and (ii) with scoring. The first strategy relies on elastic deformation of the thin-films, whereas the later depends on localized, plastic deformation caused by the scoring geometry. From the experiments on folding we identified three regimes of process operation namely: insufficient scoring, appropriate scoring, and excessive scoring. The implications of different levels of scoring were observed and understood carefully for the scoring and folding operation. Practical guidelines were developed for carrying out folding successfully and the scope of future work was discussed.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>