2026-09-20T15:06:57Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/815992022-01-13T07:54:05Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Ian W. Hunter.
Cloutier, Alison (Alison Marie)
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2013-10-24T17:33:34Z
2013-10-24T17:33:34Z
2013
2013
http://hdl.handle.net/1721.1/81599
858866517
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 113-118).
Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases that plague the inner ear. The real-time controlled linear Lorentz-force actuated jet injector developed in the MIT BioInstrumentation lab was found to be a feasible technology for possible improvement over current intratympanic drug delivery methods. Jet injection holes using a nozzle with a 50 [mu]m orifice were found to be significantly smaller than those made using a standard, 0.31 mm (30-gauge) hypodermic needle. The feasibility of using the jet injector to deliver drug to the inner ear with less tissue damage than seen in standard procedures is shown offering an avenue for improved inner ear drug delivery methods and technology.
by Alison Cloutier.
S.M.
118 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery
Thesis
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<Abstract>Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases that plague the inner ear. The real-time controlled linear Lorentz-force actuated jet injector developed in the MIT BioInstrumentation lab was found to be a feasible technology for possible improvement over current intratympanic drug delivery methods. Jet injection holes using a nozzle with a 50 [mu]m orifice were found to be significantly smaller than those made using a standard, 0.31 mm (30-gauge) hypodermic needle. The feasibility of using the jet injector to deliver drug to the inner ear with less tissue damage than seen in standard procedures is shown offering an avenue for improved inner ear drug delivery methods and technology.</Abstract>
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