2026-09-19T11:16:59Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/823332022-01-13T07:53:58Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Paula T. Hammond.
Morey, Shannon Marie
Massachusetts Institute of Technology. Department of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2013-11-18T19:10:04Z
2013-11-18T19:10:04Z
2013
2013
http://hdl.handle.net/1721.1/82333
861621344
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references (p. 38-39).
Creating new scaffolds for cells is critical to the development of new tissue engineering techniques. In this work, the synthesis of new polypeptide systems is discussed. These systems are intended for the formation of hydrogels which can then be used as cell substrates. Attempts at using the clickable synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic polypeptide with click functionality is also investigated. Additionally, the creation of a polypeptide system with two functionalities available for orthogonal click chemistry is discussed.
by Shannon Marie Morey.
S.M.
39 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
Development and study of synthetic polypeptides for biomaterial applications
Thesis
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Publication
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<Abstract>Creating new scaffolds for cells is critical to the development of new tissue engineering techniques. In this work, the synthesis of new polypeptide systems is discussed. These systems are intended for the formation of hydrogels which can then be used as cell substrates. Attempts at using the clickable synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic polypeptide with click functionality is also investigated. Additionally, the creation of a polypeptide system with two functionalities available for orthogonal click chemistry is discussed.</Abstract>
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