2026-09-18T22:49:25Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/862802022-01-13T07:53:55Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Jianzhu Chen.
Doty, Daniel, S.M. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Department of Biology.
Massachusetts Institute of Technology. Department of Biology
2014-04-25T15:48:41Z
2014-04-25T15:48:41Z
2005
2005
http://hdl.handle.net/1721.1/86280
874753595
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2005.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 10-12).
The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, and is often effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of contraction, when most effector cells die. Those that survive become memory T cells, protecting the body from subsequent influenza infections. The molecular and cellular interactions that comprise the CD8+ cytotoxic T cell response to influenza virus are of particular interest because of their implications for the prevention, treatment, and alleviation of the flu.
by Daniel Doty.
S.M.
12 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
CD8⁺ T Cell Response to Influenza Virus
Thesis
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Publication
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<Abstract>The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, and is often effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of contraction, when most effector cells die. Those that survive become memory T cells, protecting the body from subsequent influenza infections. The molecular and cellular interactions that comprise the CD8+ cytotoxic T cell response to influenza virus are of particular interest because of their implications for the prevention, treatment, and alleviation of the flu.</Abstract>
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