2026-09-24T14:14:58Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/86412022-01-13T07:54:35Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Bonnie Berger.
Bradley, Philip H. (Philip Harlan), 1973-
Massachusetts Institute of Technology. Dept. of Mathematics.
Massachusetts Institute of Technology. Department of Mathematics
2005-08-23T21:57:05Z
2005-08-23T21:57:05Z
2001
2001
http://hdl.handle.net/1721.1/8641
49612673
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2001.
Includes bibliographical references (leaves 129-137).
In this thesis, two algorithms for protein structural motif recognition are presented. A program is described which successfully recognizes the occurrence of the right-handed parallel 8-helix fold from protein sequence data alone. When run on sequences of unknown structure the program identifies the fold in a significant number of microbial outer membrane and cell-surface proteins implicated in infectious disease. A search algorithm is introduced for unsupervised discovery of protein sequence patterns that are significantly correlated with structural motifs. The algorithm identifies known, biologically relevant patterns as well as several potentially novel motifs. It is hoped that both algorithms may contribute to a better understanding of the connection between protein sequence and structure.
by Philip H. Bradley.
Ph.D.
137 leaves
11667830 bytes
11667590 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Mathematics.
Mathematical methods for protein structural motif recognition
Thesis
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