2026-09-24T19:37:01Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/89312026-06-06T01:04:31Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Paul Matsudaira.
Ait-Ghezala, Ahmed, 1976-
Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
2005-08-23T16:27:29Z
2005-08-23T16:27:29Z
2000
2000
http://hdl.handle.net/1721.1/8931
48981628
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.
Includes bibliographical references (leaf 49).
The initiative to complete the sequencing of the human genome is bringing the need for high-throughput sequencing capabilities to the forefront. We at the BioMEMS engineering group at the Whitehead Institute are designing and building a new sequencing machine that uses a 384 glass "chip" to dramatically increase sequencing rates. This thesis describes the design and implementation of two of the machine's software components. The first is a prototype application for the control of a robot used to automate sample loading. The second is a software filter that allows us to generate quality scores from data processed by Trout using Phred. I present the algorithm used to perform the filtering and show that the results are comparable to the processing of data with the Plan- Phred processing package.
by Ahmed Ait-Ghezala.
M.Eng.
S.B.
49 leaves
3894075 bytes
3893834 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Electrical Engineering and Computer Science.
Software systems for a DNA sequencer
Software systems for a deoxyribonucleic acid sequencer
Thesis
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