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Bruce R. Rosen and Joseph B. Mandeville. Sander, Christin Y. (Christin Yen-Ming) Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science 2015-02-05T18:26:46Z 2015-02-05T18:26:46Z 2014 2014 http://hdl.handle.net/1721.1/93832 900730258 Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014. Cataloged from PDF version of thesis. Includes bibliographical references (pages 147-158). Whole-brain neuroimaging is a key technique for studying brain function and connectivity. Recent advances in combining two imaging modalities - magnetic resonance imaging (MRI) and positron emission tomography (PET) - into one integrated scanner, have created the opportunity to explore the underlying neurochemistry of brain function in more detail. Imaging these dynamics plays an important role for understanding drug action and function of neurochemical pathways in the brain and is crucial, yet largely unexplored, for creating and evaluating treatment of neurological and psychiatric disorders. In this thesis, we first address technological challenges in simultaneous PET/MRI by designing, building and evaluating PET compatible MR probes for brain imaging, which enable highly sensitive dual modality imaging. We then develop simultaneous imaging methods with PET and functional MRI to assess and validate relationships between receptor occupancy and changes in brain activity due to pharmacological challenges targeting the dopamine system. Our results indicate that dopamine receptor occupancies and vascular responses are correlated in anatomical space and with pharmacological dose. Moreover, the temporal dynamics of the signals show that a direct neurovascular coupling between receptor occupancy and hemodynamics exists and that a temporal divergence between PET and fMRI can be used to investigate previously unexplored neurochemical parameters and adaptation mechanisms in vivo. Overall, our findings provide insight into dopaminergic receptor dynamics and their effects on high-level brain function, paving a way to address receptor-specific brain dysfunction effectively. by Christin Y. Sander. Ph.D. 158 pages eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Electrical Engineering and Computer Science. Simultaneous PET/fMRI for imaging neuroreceptor dynamics Simultaneous positron emission tomography/functional magnetic resonance imaging for imaging neuroreceptor dynamics Thesis application/pdf false Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="9a8ab6af-7f6a-49c4-958c-8473ee62061a"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Simultaneous PET/fMRI for imaging neuroreceptor dynamics</Title> <Subtitle>Simultaneous positron emission tomography/functional magnetic resonance imaging for imaging neuroreceptor dynamics</Subtitle> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2014</PublicationDate> <Authors> <Author> <DisplayName>Sander, Christin Y. (Christin Yen-Ming)</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Electrical Engineering and Computer Science.</Keyword> <Abstract>Whole-brain neuroimaging is a key technique for studying brain function and connectivity. Recent advances in combining two imaging modalities - magnetic resonance imaging (MRI) and positron emission tomography (PET) - into one integrated scanner, have created the opportunity to explore the underlying neurochemistry of brain function in more detail. Imaging these dynamics plays an important role for understanding drug action and function of neurochemical pathways in the brain and is crucial, yet largely unexplored, for creating and evaluating treatment of neurological and psychiatric disorders. In this thesis, we first address technological challenges in simultaneous PET/MRI by designing, building and evaluating PET compatible MR probes for brain imaging, which enable highly sensitive dual modality imaging. We then develop simultaneous imaging methods with PET and functional MRI to assess and validate relationships between receptor occupancy and changes in brain activity due to pharmacological challenges targeting the dopamine system. Our results indicate that dopamine receptor occupancies and vascular responses are correlated in anatomical space and with pharmacological dose. Moreover, the temporal dynamics of the signals show that a direct neurovascular coupling between receptor occupancy and hemodynamics exists and that a temporal divergence between PET and fMRI can be used to investigate previously unexplored neurochemical parameters and adaptation mechanisms in vivo. Overall, our findings provide insight into dopaminergic receptor dynamics and their effects on high-level brain function, paving a way to address receptor-specific brain dysfunction effectively.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>