2026-09-21T06:08:08Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/964512026-06-16T18:55:30Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Moungi G. Bawendi.
Wei, He, Ph.D. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Department of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2015-04-08T18:01:49Z
2015-04-08T18:01:49Z
2014
2014
http://hdl.handle.net/1721.1/96451
905969154
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2014.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references (pages 130-136).
Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice. Functionalized SPIONs demonstrated the ability of specific labeling. Finally, the hydrophilic SPIONs have potential as a non-toxic alternative to Gadolinium based contrast agents for T₁-weighted magnetic resonance imaging (MRI) and they have shown potential in multicolor MRI as well as magnetic particle imaging.
by He Wei.
Ph.D.
136 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
Synthesis and development of hydrophilic iron oxide nanoparticles for biomedical applications
Thesis
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<Abstract>Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice. Functionalized SPIONs demonstrated the ability of specific labeling. Finally, the hydrophilic SPIONs have potential as a non-toxic alternative to Gadolinium based contrast agents for T₁-weighted magnetic resonance imaging (MRI) and they have shown potential in multicolor MRI as well as magnetic particle imaging.</Abstract>
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