2026-09-20T00:11:59Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/986352022-01-13T07:53:55Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Graham C. Walker.
Zhao, Yimin, S.M. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Department of Biology.
Massachusetts Institute of Technology. Department of Biology
2015-09-17T19:01:13Z
2015-09-17T19:01:13Z
2015
2015
http://hdl.handle.net/1721.1/98635
920673446
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 27-29).
NusA has long known to be a bona fide transcription factor that functions in both termination and antitermination. However, its role in DNA repair and damage tolerance has not been explored until recently. Cohen et al. proposed for the first time that NusA functions as a coupling factor in transcription-coupled translesion synthesis (TC-TLS) and nucleotide excision repair (TCR) processes. A very recent paper by Nudler's lab further supports Cohen's NusA-dependent TCR model. The objectives of the work described here are to gain a deeper understanding of the precise mechanism NusA uses to facilitate DNA repair and damage tolerance.
by Yimin Zhao.
S.M.
29 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
Thesis
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<Abstract>NusA has long known to be a bona fide transcription factor that functions in both termination and antitermination. However, its role in DNA repair and damage tolerance has not been explored until recently. Cohen et al. proposed for the first time that NusA functions as a coupling factor in transcription-coupled translesion synthesis (TC-TLS) and nucleotide excision repair (TCR) processes. A very recent paper by Nudler's lab further supports Cohen's NusA-dependent TCR model. The objectives of the work described here are to gain a deeper understanding of the precise mechanism NusA uses to facilitate DNA repair and damage tolerance.</Abstract>
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