2026-09-21T20:04:53Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/992842026-06-17T14:42:52Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Jeff Gore.
Yurtsev, Evgene
Massachusetts Institute of Technology. Department of Physics.
Massachusetts Institute of Technology. Department of Physics
2015-10-14T15:03:10Z
2015-10-14T15:03:10Z
2015
2015
http://hdl.handle.net/1721.1/99284
922884934
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 132-138).
Through a combination of experiments and modeling, I explored how inactivation of antibiotics by antibiotic-resistant bacteria affects the evolution of antibiotic resistance in two simple microbial communities. First, I examined the interaction between a resistant strain and a sensitive strain of the bacteria Escherichia coli in the presence of the [beta]-lactam antibiotic ampicillin. Second, I investigated whether two strains of Escherichia coli can form a cross-protection mutualism in a multi-drug environment containing the antibiotics ampicillin and chloramphenicol. In both experimental systems, I found that inactivation of antibiotics by resistant bacteria is an important cooperative behavior which enables microbes to help each other survive in otherwise lethal antibiotic concentrations. The rich dynamical behaviors that arise even in these simple systems highlight the inherent challenge in deciphering the workings of more complex microbial communities.
by Evgene Yurtsev.
Ph.D.
138 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Physics.
Cooperative behaviors in the evolution of antibiotic resistance
Thesis
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<Abstract>Through a combination of experiments and modeling, I explored how inactivation of antibiotics by antibiotic-resistant bacteria affects the evolution of antibiotic resistance in two simple microbial communities. First, I examined the interaction between a resistant strain and a sensitive strain of the bacteria Escherichia coli in the presence of the [beta]-lactam antibiotic ampicillin. Second, I investigated whether two strains of Escherichia coli can form a cross-protection mutualism in a multi-drug environment containing the antibiotics ampicillin and chloramphenicol. In both experimental systems, I found that inactivation of antibiotics by resistant bacteria is an important cooperative behavior which enables microbes to help each other survive in otherwise lethal antibiotic concentrations. The rich dynamical behaviors that arise even in these simple systems highlight the inherent challenge in deciphering the workings of more complex microbial communities.</Abstract>
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