Painting blood vessels and atherosclerotic plaques with an adhesive drug depot
Author(s)
Kastrup, Christian; Nahrendorf, Matthias; Figueiredo, Jose Luiz; Lee, Haeshin; Kambhampati, Swetha; Lee, Timothy; Cho, Seung Woo; Gorbatov, Rostic; Iwamoto, Yoshiko; Dang, Tram T.; Dutta, Partha; Yeon, Ju Hun; Cheng, Hao; Vegas, Arturo; Siegel, Cory D.; MacDougall, Samantha; Okonkwo, Michael E.; Thai, Anh; Stone, James R.; Coury, Arthur J.; Weissleder, Ralph; Langer, Robert; Anderson, Daniel Griffith; Pritchard, Christopher D., (Christopher David); ... Show more Show less
DownloadKastrup-2012-Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot.pdf (1.353Mb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drug-eluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.
Date issued
2012-12Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MITJournal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Kastrup, C. J., M. Nahrendorf, J. L. Figueiredo, H. Lee, S. Kambhampati, T. Lee, S.-W. Cho, et al. “Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.” Proceedings of the National Academy of Sciences 109, no. 52 (December 26, 2012): 21444-21449.
Version: Final published version
ISSN
0027-8424
1091-6490