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1 |
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Overview |
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Lecture Notes (PDF)
Handout (PDF)
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2 |
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Cells of Immune System & Innate Immunity |
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Lecture Notes (PDF)
Handout (PDF)
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3 |
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Antibodies
Antibody-Dependent Protection Mechanisms |
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Lecture Notes (PDF 1 & PDF 2)
Handouts (PDF 1 & PDF 2)
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4 |
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Antigen Receptors & Dev. of Diversity
T Lymphocyte Development |
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Handouts (for Antigen Receptors) (PDF) and
Di Noia, J. and Michael S. Neuberger. "Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase" Nature, Vol. 419, 5 September 2002, pp. 43-48.
Handout (for T Lymphocyte Development) (PDF)
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5 |
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B Lymphocyte Dev & Activation |
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Handout (PDF)
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6 |
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A Multiplicity of Problems -- Tutorial
Clinic at MGH |
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7 |
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Cell-mediated Immunity |
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Handouts (PDF) and
Abbas, A., J. Pober, A. Lichtman, and W. B. Saunders. Cellular and Molecular Immunology. 4th edition, 2000.
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8 |
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A Complex Case -- Tutorial
Student Presentations 1 & 2: Crohn's/XLLS
Clinic at MGH |
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9 |
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Lymphocyte Homing |
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Lecture Notes (PDF)
Handout
Cyster, Jason G. "Chemokines and Cell Migration in Secondary Lymphoid Organs." Science 286, (10 Dec. 1999): 2098-2102.
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10 |
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MHC/Antigen Presentation |
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Lecture Notes (PDF) |
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11 |
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Midterm Review Session |
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12 |
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Midterm Exam |
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13 |
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Too Many Infections -- Tutorial |
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14 |
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Autoimmunity |
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15 |
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A Bloody Glove -- Tutorial
Lymphocyte Activation, Cytokines, Costim |
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Handout (PDF)
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16 |
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Presentations 3 & 4: Hyper-IgM and TB |
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17 |
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Fever -- Tutorial
Presentations 5 & 6: Lymphohistiocytosis/Asthma |
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18 |
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Transplantation Immunology
Presentations 7 & 8: Chronic Granulomatous/MS |
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Lecture Notes (PDF) |
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19 |
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Immunology of HIV Disease |
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Lecture Notes (PDF) |
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20 |
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Costimulation
Presentation 9: Lymphoprolif Syndrome |
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Lecture Notes (PDF) |
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21 |
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A Boston T Party -- Tutorial
Bone Marrow Transplantation |
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22 |
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Memory and Death in Immune System
IgE System & Immediate Type Hypersens |
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Lecture Notes (PDF)
Handouts (PDF) and
Rosen, Fred S., Max D. Cooper, and Ralph J. P. Wedgwood. "The Primary Immunodeficiencies." The New England Journal of Medicine 333, 7 (17 Aug. 1995): 431-440.
Buckley, Rebecca H. "Primary Immunodeficiency Diseases Due to Defects in Lymphocytes." Advances in Immunology 343, 18: 1313-1324.
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23 |
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Shock Therapy -- Tutorial
Presentations 10 & 11: SLE/Leprosy |
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24 |
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Primary Immunodeficiencies
Breakpoints -- Tutorial |
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25 |
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Presentations 12 & 13: NHL/RA |
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26 |
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Tumor Immunity |
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Handout (PDF) |
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27 |
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Rheumatoid Arthritis and SLE |
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28 |
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Apoptosis, An Overview |
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29 |
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Pre-Midterm Material Review Session
Novel Approaches to Gene Targeting |
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30 |
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Inflammatory Bowel Disease |
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31 |
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Post-midterm Material Review Session |
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32 |
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Immunodeficiency Syndromes/Review |
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Lecture Notes (PDF) |
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33 |
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HST 175 Final Examination |
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