Browsing by Title
Now showing items 28230-28249 of 143334
-
Defining System Changeability: Reconciling Flexibility, Adaptability, Scalability, and Robustness for Maintaining System Lifecycle Value
(2007-06-24)Designing and maintaining systems in a dynamic contemporary environment requires a rethinking of how systems provide value to stakeholders over time. Classically, two different approaches to promoting value sustainment ... -
Defining System Changeability: Reconciling Flexibility, Adaptability, Scalability, and Robustness for Maintaining System Lifecycle Value
(2007)Designing and maintaining systems in a dynamic contemporary environment requires a rethinking of how systems provide value to stakeholders over time. Classically, two different approaches to promoting value sustainment ... -
Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
(Massachusetts Institute of Technology, 2005)Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Saccharomyces cerevisiae RNR is a class I RNR composed of a dimeric large subunit (RI), containing the active site and ... -
Defining the American public realm : an escape from tradition
(Massachusetts Institute of Technology, 1993) -
Defining the contributors to mammalian cell mass
(Massachusetts Institute of Technology, 2017)Proliferation can be thought of as the sum of many biosynthetic processes. To proliferate, a cell must not only physically divide but must also newly synthesize each of its components as it progresses through the cell ... -
Defining the core essential genome of Pseudomonas aeruginosa
(Proceedings of the National Academy of Sciences, 2019-05)© 2019 National Academy of Sciences. All rights reserved. Genomics offered the promise of transforming antibiotic discovery by revealing many new essential genes as good targets, but the results fell short of the promise. ... -
Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates
(Public Library of Science (PLoS), 2022)<jats:p>Despite the rapid creation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines, the precise correlates of immunity against severe Coronavirus Disease 2019 (COVID-19) are still unknown. Neutralizing ... -
Defining the ecological and physiological traits of phytoplankton across marine ecosystem
(Massachusetts Institute of Technology, 2016)Marine phytoplankton are central players in the global carbon cycle, responsible for nearly half of global primary production. The identification of the factors controlling phytoplankton ecology, physiology, and, ultimately, ... -
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(Elsevier, 2016-06)Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated ... -
Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies
(Nature Publishing Group, 2013-11)Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived ... -
Defining the gut microbiota in individuals with periodontal diseases: an exploratory study
(Co-action Publishing, 2018-06)Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction. Methods: Stool samples ... -
Defining the human endothelial transcriptome
(Massachusetts Institute of Technology, 2005)Advances in microarray technology facilitate the study of biological systems at a genome-wide level. Meaningful analysis of these transcriptional profiling studies, however, demands the concomitant development of novel ... -
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
(Elsevier, 2016-06)Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary ... -
Defining the molecular basis for the β-catenin and CDC73 interaction
(Massachusetts Institute of Technology, 2022-05)RNA polymerase II (Pol II) is required for expression of protein coding genes. To initiate gene transcription, Pol II is recruited to gene promoters by transcription factors. Gene specific transcription factors, including ... -
Defining the needs of women offenders.
(Massachusetts Institute of Technology, 1973) -
Defining the Precision and Sequence Determinants of Protein Synthesis Rates
(Massachusetts Institute of Technology, 2022-09)Protein synthesis drives cellular proliferation and produces the primary effectors of biological function. Understanding how protein synthesis rates are controlled is therefore a central question of quantitative biology. ... -
Defining the public three moments of audience address in 20th century artistic production
(Massachusetts Institute of Technology, 1991)This paper examines strategies of audience address as manifest in the work of the Russian avant-garde of the 1920s, the sculptural practices of the American Minimalists and the critics who served to define their endeavors, ... -
Defining the role of aneuploidy throughout tumorigenesis
(Massachusetts Institute of Technology, 2021)Aneuploidy is a state of genome imbalance which alters the copy number of whole chromosomes. While aneuploidy is rare in healthy tissues, it is one of the most common features of cancerous tumors. Studies of aneuploid yeast ... -
Defining the role of elastic lubricants and micro textured surfaces in lubricated, sliding friction
(Massachusetts Institute of Technology, 2008)Solutions for reducing friction in sliding, lubricated systems include modifying lubricant rheology using polymers and adding a micro-scale texture to the sliding surfaces, but the mechanism of how lubrication properties ... -
Defining transit oriented development (TOD) potential along the commuter line stations in Jakarta
(Massachusetts Institute of Technology, 2018)Transit oriented development (TOD) has been an emerging concept in Jakarta, particularly since the construction of the new Mass Rapid Transit (MRT) and Light Rail Transit (LRT). Besides the two incoming new transits, Jakarta ...
