Browsing Doctoral Theses by Author "Xie, Stephanie Zhi-Juan"
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Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
Xie, Stephanie Zhi-Juan (Massachusetts Institute of Technology, 2007)The ubiquity of aneuploidy in human cancers, particularly solid tumors, suggests a fundamental link between errors in chromosome segregation and tumorigenesis. The spindle checkpoint ensures accurate chromosome segregation ...