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An analytic model of the Cochlea and functional interpretations
(Massachusetts Institute of Technology, 2017)
The cochlea is part of the peripheral auditory system that has unique and intriguing features - for example it acts as a wave-based frequency analyzer and amplifies traveling waves. The human cochlea is particularly ...
Genomic profiling and perturbation of Hepatitis B virus infection
(Massachusetts Institute of Technology, 2016)
The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, ...
Dynamics of human decision-making : vestibular perception and neural correlates
(Massachusetts Institute of Technology, 2017)
When making daily decisions, people naturally ask two questions: how soon can I make a decision, and is it a good decision? In experimental setting, humans can subjectively yet quantitatively assess choice confidence (i.e. ...
MRI based cerebral oxygenation measures in humans : technical development for use across lifespan
(Massachusetts Institute of Technology, 2018)
MRI based cerebral oxygenation measures could enable brain-centered clinical care and improve understanding of brain energy use throughout human development. We made technical improvements to two MR oxygenation imaging ...
Noninvasive disease diagnostics using engineered synthetic urinary biomarkers
(Massachusetts Institute of Technology, 2016)
Accurate, timely, and effective diagnosis is the first step in appropriately treating disease. Many diseases have confusing symptoms, nonspecific biomarkers, or require invasive biopsy; these factors and others contribute ...
Computational imaging and analysis in breast cancer
(Massachusetts Institute of Technology, 2018)
The conventional pathologic analysis of malignancies involves a qualitative characterization and integration of several factors including tumor size, general degree of differentiation, tumor heterogeneity, mitotic rate, ...
Acoustical-molecular techniques for magnetic resonance imaging
(Massachusetts Institute of Technology, 2016)
Magnetic resonance imaging (MRI) is a remarkably flexible diagnostic platform due to the variety of clinically relevant physical, chemical, and biological phenomena it can detect. In addition to the host of endogenous ...
Engineered approaches to querying the microenvironment of cancer metastasis
(Massachusetts Institute of Technology, 2013)
Cancer metastasis is the underlying mechanism of 90% of cancer-related deaths, yet few therapeutics exist that directly target it. Part of this scarcity is attributable to a general lack of knowledge with regards to the ...
Acoustic features of impaired articulation due to amyotrophic lateral sclerosis
(Massachusetts Institute of Technology, 2017)
Progressive bulbar motor deterioration resulting from amyotrophic lateral sclerosis (ALS) leads to speech impairment. Despite the devastating consequences of speech impairment to life quality, few options are available to ...
Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
(Massachusetts Institute of Technology, 2017)
Cancer is one of leading cause of deaths, and responsible for 8.2 million deaths worldwide. Especially, 70% of deaths from cancer occur in low or mid income countries. In order to deliver affordable and accessible cancer ...