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Optical transient grating measurements of micro/nanoscale thermal transport and mechanical properties
(Massachusetts Institute of Technology, 2015)
The laser-based transient grating technique was used to study phonon mediated thermal transport in bulk and nanostructured semiconductors and surface wave propagation in a monolayer of micron sized spheres. In the transient ...
An analysis of exciton transport, electron tunneling, and electromigration in nanotube and nanowire systems
(Massachusetts Institute of Technology, 2016)
Herein three systems - electromigration in metal nanowires, electron tunneling in single-molecules, and carbon nanotube photovoltaics - are investigated. In the first area, electromigrative failure of metal nanowires has ...
Structure and function of the Influenza membrane protein M2 by magic angle spinning NMR and dynamic nuclear polarization
(Massachusetts Institute of Technology, 2014)
Determination of the 3D structure of membrane proteins is a frontier that is rapidly being explored due to the importance of membrane proteins in regulating cellular processes and because they are the target of many drugs. ...
High field DNP and cryogenic MAS NMR : novel instrumentation and applications
(Massachusetts Institute of Technology, 2014)
Solid State Nuclear Magnetic Resonance (ssNMR) spectroscopy has blossomed over the last two decades. As ssNMR is progressively applied to more challenging systems, the sensitivity remains one of its major limiting factors. ...
The prior thiol capture method for peptide synthesis
(Massachusetts Institute of Technology, 1984)
Enzyme mediated labeling of synaptic proteins for proteomics and imaging
(Massachusetts Institute of Technology, 2016)
The neuronal synapse is one of the most important cellular structures in neuroscience. It is the junction through which signaling occurs between neurons that in aggregate, mediates complex physiological brain function. At ...
Automated flow peptide synthesis
(Massachusetts Institute of Technology, 2018)
Though reported by Merrifield nearly sixty years ago, batch solid phase peptide synthesis remains slow at minutes to hours per residue. Here we report a fully automated, flow based approach to solid phase polypeptide ...
The role of XBP1s in the unfolded protein response and N-linked glycosylation
(Massachusetts Institute of Technology, 2020)
The secretory pathway processes approximately one-third of the cellular proteome, modifying proteins with diverse chemical structures such as carbohydrates. These modifications can help guide protein folding and expand the ...
The design and synthesis of benzodithiophene-containing poly(arylene ethynylene)s
(Massachusetts Institute of Technology, 2018)
In Chapter 1, we provide an overview of the properties and applications of conjugated polymers, with a particular focus on poly(arylene ethynylene)s. We discuss the synthesis and photophysical properties of poly(arylene ...
Design, synthesis, and biological evaluation of diketopiperazine based ionizable lipids for the in vivo delivery of messenger RNA
(Massachusetts Institute of Technology, 2016)
Thousands of human diseases could be treated by selectively increasing the intracellular concentration of specific proteins. The successful delivery of messenger RNA (mRNA) to target cells in the body could accomplish this ...