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Patterns of linkage disequilibrium in the human genome
(Massachusetts Institute of Technology, 2002)
Although enormous progress has occurred in the field of human genetics, the cloning of complex trait mutations remains a challenging and unresolved process. This continuing difficulty is responsible for an ever-increasing ...
Mnemonic information in the rodent hippocampus during wake and sleep states
(Massachusetts Institute of Technology, 2002)
To investigate the representation of information in the hippocampus during memory processes, we simultaneously monitored the spiking activity of many single neurons in freely behaving rats during spatial locomotor tasks ...
The role of nonclassical MHC class I products in the development and function of CD8+ T cells
(Massachusetts Institute of Technology, 2002)
Major histocompatibility complex (MHC) class I products present pathogen-derived peptides to CD8+ cytotoxic T cells. This interaction mediates the detection and clearance of intracellular infections. Emphasis has been ...
Beta 3 integrins : negative regulators of angiogenesis
(Massachusetts Institute of Technology, 2002)
A method was developed to isolate and purify primary murine endothelial cells from lung tissue (MLEC). The cells generated by this method were characterized by immuno-fluorescence detection and FACS analysis and expressed ...
Glycosaminoglycan biosynthesis controls C. elegans vulval morphogenesis and is required for the first cell division during embryogenesis
(Massachusetts Institute of Technology, 2002)
Morphogenesis is critical to the development of multicellular organisms. Morphogenesis is also a complex process that requires the coordination of many events, including cell division, cytoskeletal reorganization, cell-cell ...
Genome-wide expression and location profiling in Saccharomyces cerevisiae : experimental and graphical analysis
(Massachusetts Institute of Technology, 2002)
Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the ...
Mark-recapture statistics and demographic analysis
(Massachusetts Institute of Technology, 2002)
Mark-recapture analysis of populations is becoming an important tool in population biology. Mark-recapture methods can be used to estimate transition probabilities among life-stages from capture histories of marked individuals ...
Cloning and characterization of E2F6, a novel member of the E2F transcription factor family
(Massachusetts Institute of Technology, 2002)
The E2F family of proteins plays a critical role in the regulation of genes that are essential for progression through the cell-cycle. Based upon sequence homology and functional properties, the E2F group can be subdivided ...
Identification and characterization of GRP50 : a novel Golgi-associated ankyrin repeat protein
(Massachusetts Institute of Technology, 2002)
This thesis describes the identification and characterization of a novel gene, GRP50 (Golgi-associated ankyrin repeat protein of 50 kilodaltons), which encodes a highly conserved mammalian protein exhibiting a unique ...
The retinoblastoma gene family in tumor suppression and development
(Massachusetts Institute of Technology, 2002)
The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development ...