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Determination of cell fate selection during phage lambda Infection
(Massachusetts Institute of Technology, 2009)
Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes: for example, some cells lyse while others survive as lysogens. A quantitative molecular model of lambda infection supports the ...
The function of E2F6 in the Polycomb complex
(Massachusetts Institute of Technology, 2005)
The E2F family of transcription factors are known cell cycle regulators that function at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, ...
Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans
(Massachusetts Institute of Technology, 2002)
Programmed cell death is important in development, homeostasis, and disease. In the nematode Caenorhabditis elegans, four genes, egl-1, ced-9, ced-4, and ced-3, control the execution of cell death and define a molecular ...
Targeting and function of mammalian microRNAs
(Massachusetts Institute of Technology, 2009)
In the span of a few short years, animal microRNAs have become recognized as broad regulators of gene expression, largely in part due to our improved understanding of how animal microRNAs recognize their targets. Crucial ...