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Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug
(Massachusetts Institute of Technology, 2004)
(cont.) with recombinant material. The in vitro system established in this study will facilitate the investigation of platinum-DNA damage by DNA repair processes and help elucidate the role of specific post-translational ...
Insight into the structure and function of empty class II major histocompatibility complexes
(Massachusetts Institute of Technology, 2004)
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at the cell surface for interaction with CD4+ T cells as part of the system by which the immune system surveys the body for signs of ...
Spectroscopic investigations of hydrogen bond dynamics in liquid water
(Massachusetts Institute of Technology, 2004)
Many of the remarkable physical and chemical properties of liquid water are due to the strong influence hydrogen bonds have on its microscopic dynamics. However, because of the fast timescales involved, there are relatively ...
Annulation strategies for the synthesis of azulenes and polycyclic nitrogen heterocycles
(Massachusetts Institute of Technology, 2004)
Highly convergent annulation strategies have been developed for the synthesis of azulenes and polycyclic nitrogen heterocycles. Specifically, substituted azulenes have been synthesized via a ring expansion-annulation ...
Novel synthetic routes to high-quality II-VI colloidal nanocrystals : controlled growth using mild precursors in the presence of selected ligands
(Massachusetts Institute of Technology, 2004)
New sensor applications of poly(phenylene ethynylene)s
(Massachusetts Institute of Technology, 2004)
(cont.) Fluorescence quenching by these analytes was shown to be assisted by specific host-guest interactions involving the calix[4]arene macrocycles.
Molecular engineering strategies for expanding the capabilities of fluorescent zinc (II) sensors
(Massachusetts Institute of Technology, 2004)
(cont.) affords the two fluorophores, such that excitation of the coumarin at 445 nm and measurement of the emission at 488 nm affords information of the amount of sensor present, while excitation of the fluorescein at 505 ...
Structural studies of bacterial multicomponent monooxygenases : insights into substrate specificity, diiron center tuning and component interactions
(Massachusetts Institute of Technology, 2004)
(cont.) α-subunit cavities. The presence of 6-bromohexan-l-ol induces one of the active site helices to adopt a [pi] conformation. Together, these findings suggest modes by which molecules may move through the MMOH cavities ...
Carbonyl ylide cycloadditions of dicobalt carbonyl complexes of propargylic aldehydes
(Massachusetts Institute of Technology, 2004)
The intermolecular, three-component carbonyl ylide cycloaddition of a diazo compound, aldehyde, and carbon-carbon multiple bond is a powerful method to construct five-membered oxygen heterocycles. An adjacent dicobalt ...
New chiral molybdenum metathesis catalysts : application to the enantioselective preparation of cyclic amines
(Massachusetts Institute of Technology, 2004)
Optically pure (R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-napthol was derivatized with mesityl groups in the 3 and 3' positions to give (R)-MES₂BitetH₂ 1.43. Addition of the di-potassium salt of 1.43 to (Ar[sub]prN)Mo(C ...