Search
Now showing items 1-10 of 11
Novel palladium precatalysts and their application in cross- coupling reactions and copper-catalyzed enantioselective ring formation
(Massachusetts Institute of Technology, 2015)
Chapters 1 - 3. A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the ...
New reactivity and selectivity in transition metal-catalyzed C-C and C-N bond forming processes
(Massachusetts Institute of Technology, 2015)
Part I. Palladium-Catalyzed Carbon-Carbon Bond Forming Cross-Couplings Chapter 1. Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki-Miyaura Cross-Coupling of Allylboronates and Aryl Halides An orthogonal set of ...
The Pd-catalyzed fluorination of (hetero)aryl bromides and triflates
(Massachusetts Institute of Technology, 2015)
Chapter 1: This chapter details mechanistic work regarding the reductive elimination of electron-rich aryl fluorides from L-Pd(Ar)F species. An unexpected dearomatization/arylation process of Pd(II) complexes bearing bulky ...
New Pd and Cu-based catalysts for carbon-heteroatom bond formation
(Massachusetts Institute of Technology, 2015)
The research presented in this dissertation is aimed at the development of novel methodologies for carbon-heteroatom cross-coupling reactions catalyzed by late-transition metals. Both palladium and copper are central to ...
The nickel-catalyzed Mizoroki-Heck reaction : high regioselectivity in Olefin migratory insertion and photoredox-enabled indoline formation
(Massachusetts Institute of Technology, 2015)
[chemical formula and color illustrations ...] Achieving high selectivity in the Heck reaction of electronically unbiased alkenes has been a longstanding challenge. Using a nickel-catalyzed cationic Heck reaction, we were ...
Development of new transition metal catalysts for C-N bond formation and continuous flow processes for C-F bond formation
(Massachusetts Institute of Technology, 2015)
The work presented in this dissertation addresses the development of new methodologies and processes to form carbon-nitrogen (C-N) and carbon-fluorine (C-F) bonds. The development of methods for the formation of C-N and ...
Development of new catalytic transformations and reagents for the construction of C-N and C-S bonds
(Massachusetts Institute of Technology, 2015)
Chapter 1. Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas. An efficient method for palladium-catalyzed cross-coupling of aryl chlorides ...
Chiral phosphine-catalyzed asymmetric transformations of allenoates and alkynoates and photoinduced, copper-catalyzed C-N couplings with aromatic nitrogen ceterocycles
(Massachusetts Institute of Technology, 2015)
Chapter 1 describes the development of chiral biphenyl-derived phosphepines and their application as catalysts for an asymmetric [4 + 1] annulation to form functionalized cyclopentenes bearing a non-spirocyclic quaternary ...
Nickel precatalysts as enabling tools for catalytic coupling reactions
(Massachusetts Institute of Technology, 2015)
[Chemical formula] A series of air-stable nickel complexes of the form L₂Ni(aryl)X (L = monodentate phosphine, X = Cl, Br) and LNi(aryl)X (L = bis-phosphine) have been synthesized and are presented as a library of precatalysts ...
Development of Epipolythiodiketopiperazine syntheses and the total synthesis of diketopiperazine alkaloids
(Massachusetts Institute of Technology, 2015)
I. The Development of Epipolythiodiketopiperazine (ETP) Syntheses Epipolythiodiketopiperazine (ETP) alkaloids represent a structurally complex and biologically potent class of secondary fungal metabolites and these molecules ...