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Development and application of new strategies for synthesis of complex diketopiperazine alkaloids
(Massachusetts Institute of Technology, 2018)
I. Quantitative Modeling of Bis(pyridine)silver (I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates The bis(pyridine)silver(I) permanganate promoted ...
Development of new transition metal-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond forming processes
(Massachusetts Institute of Technology, 2018)
Chapter 1. Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Dramatic Effect of TESCF₃ as an Additive A method for the synthesis of cyclic vinyl fluorides with high levels of regiochemical fidelity has been ...
Enabling the use of unstable, hazardous reagents with continuous flow synthesis
(Massachusetts Institute of Technology, 2018)
[chemical formula] Highly functionalized 2-arylindoles were synthesized from 2-alkenylarylisocyanides and arylboronic acids using a simple, inexpensive copper catalyst. The reaction exhibits excellent functional group ...
Total synthesis of cyclotryptamine and diketopiperazine alkaloids and biosynthetic pathway investigation of unsymmetrical diketopiperazine dimers
(Massachusetts Institute of Technology, 2018)
I. Total Synthesis of (-)-Hodgkinsine, (-)-Calycosidine, (-)-Hodgkinsine B, (-)-Quadrigemine C and (-)-Psycholeine The enantioselective total synthesis of (-)-hodgkinsine, (-)-calycosidine, (-)-hodgkinsine B, (-)- quadrigemine ...
Developments and applications of methods for palladium- and copper-catalyzed carbon-nitrogen bond formation
(Massachusetts Institute of Technology, 2018)
The studies presented in this dissertation are aimed at the development and application of methodologies that enable carbon-nitrogen (C-N) bond formation catalyzed by late transition metals such as palladium and copper. ...
Synthesis and anticancer evaluation of agelastatin alkaloid derivatives and enantioselective total synthesis of aspidosperma alkaloids
(Massachusetts Institute of Technology, 2018)
I. Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis The synthesis of new agelastatin alkaloid derivatives and their anticancer evaluation in the context of the ...