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Modeling and analysis of single-molecule experiments
(Massachusetts Institute of Technology, 2005)
Single molecule experiments offer a unique window into the molecular world. This window allows us to distinguish the behaviors of individual molecules from the behavior of bulk by observing rare events and heterogeneity ...
Two-dimensional polymer synthesis : towards a two-dimensional replicating system for nanostructures
(Massachusetts Institute of Technology, 2005)
The general concept of a replicating monolayer system is introduced as a new method of nanostructure synthesis. One possible implementation of a 2-D replicating system is pursued which uses a diacetylene moiety for ...
Polaritonics : an intermediate regime between electronics and photonics
(Massachusetts Institute of Technology, 2005)
This thesis contains the foundational work behind the field of polaritonics. Corresponding to a frequency range from roughly 100 gigahertz up to 10 terahertz, polaritonics bridges the gap between electronics and photonics. ...
Laboratory measurements and modeling of trace atmospheric species
(Massachusetts Institute of Technology, 2005)
Trace species play a major role in many physical and chemical processes in the atmosphere. Improving our understanding of the impact of each species requires a combination of laboratory exper- imentation, field measurements, ...
Poly(phenylene ethynylene)s in biosensor applications
(Massachusetts Institute of Technology, 2005)
Conjugated polymers have shown remarkable sensitivity for the detection of a variety of analytes, ranging from explosives to biological molecules such as DNA. This thesis presents three new applications of poly(phenylene ...
Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
(Massachusetts Institute of Technology, 2005)
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Saccharomyces cerevisiae RNR is a class I RNR composed of a dimeric large subunit (RI), containing the active site and ...
Enantioselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes. Synthesis of amphidinolides T1 and T4 via catalytic, stereoselective macrocyclizations
(Massachusetts Institute of Technology, 2005)
I. Enantioselective Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes Allylic alcohol synthesis via a nickel-catalyzed reductive coupling reaction of alkylsubstituted alkynes and aldehydes was studied for ligand ...
NMR application and development : study of the ribosomal RNA-L11 complex
(Massachusetts Institute of Technology, 2005)
The L11 protein of the large ribosomal subunit binds to a highly conserved domain of the 23S rRNA and jointly with RNA mediates GTPase activity of elongation and release factors. It consists of a C-terminal domain, which ...
Reductive coupling and related reactions with Mo and Ti tris- anilides
(Massachusetts Institute of Technology, 2005)
Chapter 1: The capability of Mo(N[t-BulAr)₃ to act as a powerful one, two, and three electron reductant have been previously demonstrated. In this work, we show that Mo(NIt-BulAr)₃ forms a metastable adduct with the moderate ...
Selective, nickel-catalyzed carbon-carbon bond-forming reactions of alkynes
(Massachusetts Institute of Technology, 2005)
Catalytic addition reactions to alkynes are among the most useful and efficient methods for preparing diverse types of substituted olefins. Controlling both regioselectivity and (EIZ)- selectivity in such transformations ...