Doctoral Theses: Recent submissions
Now showing items 1-3 of 23065
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Engineering TEV Protease Specificity: An Exploration of Machine Learning and High-Throughput Experimentation for Protein Design
(Massachusetts Institute of Technology, 2025-05)Engineering sequence-specific proteases would enable a wide variety of therapeutic applications in diseases ranging from cancer to Parkinson’s disease. However, many previous experimental and physics-based attempts at ... -
Learning-Guided Optimization for Intelligent Mobility Systems
(Massachusetts Institute of Technology, 2025-05)Efficient and reliable mobility systems are essential to modern-day society, with broad impacts ranging from day-to-day commuting, public transportation, emergency response to last-mile package delivery and freight logistics. ... -
Top-down and bottom-up interactions for cortical bursting
(Massachusetts Institute of Technology, 2025-05)High-frequency burst firing occurs throughout the mammalian cortex in vivo, yet both the underlying mechanisms and functional roles of bursts are unclear. Burst firing in brain slices is strongly modulated by the activity ...
