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Improvement of cleaning effectiveness through Statistical Process Control in active pharmaceutical ingredient (API) manufacturing
(Massachusetts Institute of Technology, 2018)
This thesis presents work that was done to improve the effectiveness of cleaning processes at an active pharmaceutical ingredient (API) manufacturing site that was in the phase of engineering trials and cleaning cycle ...
Investigation of integrally-heated tooling and thermal modeling methodologies for the rapid cure of aerospace composites
(Massachusetts Institute of Technology, 2015)
Carbon Fiber Reinforced Polymer (CFRP) composite manufacturing requires the CFRP part on the associated tool to be heated, cured, and cooled via a prescribed thermal profile. Current methods use large fixed structures such ...
Forecasting and planning for a multi-product seasonal production facility
(Massachusetts Institute of Technology, 2011)
With increasing cost pressure on commodity vaccine products, Novartis Vaccines & Diagnostics is continually looking for ways to improve operating efficiencies and decrease costs. As the largest drug product manufacturing ...
Optimization of shake inspections
(Massachusetts Institute of Technology, 2011)
The Boeing 737 program has recently announced an increase in the production rate from 31.5 airplanes per month to 35 airplanes per month. Throughout the production value stream, opportunities to improve quality and reduce ...
Lean transformation and relocation of jet engine assembly operations
(Massachusetts Institute of Technology, 2011)
As part of continuing lean transformation efforts at Pratt & Whitney, the Middletown Engine Center has turned its focus on the GP7000 turbofan engine as a target for lean implementation. Projected increases in GP7000 ...
A design methodology for the user interface of an electromechanical parts database
(Massachusetts Institute of Technology, 2013)
In an increasingly complex supply chain, the use of a structured methodology for locating applicable existing parts during the design process can help a large-volume manufacturer to encourage the reuse of components already ...
Strategic sourcing in a direct import supply chain with increasing globalization trends while mitigating risk
(Massachusetts Institute of Technology, 2013)
This thesis explores how a retailer should determine whether to source goods domestically vs. directly by imports through international sourcing. Through the research a landed cost model was developed and designed to ...
Improving the inbound supply chain through dynamic pickup windows
(Massachusetts Institute of Technology, 2014)
Amazon is one of the world's largest retailers with revenues of $74.5 billion in 2013 and 22% growth over 2012. As Amazon continues to grow and offer greater selection, more products are flowing through an expanding inbound ...
Framework and strategies for reducing aircraft lead time
(Massachusetts Institute of Technology, 2014)
Aircraft are complex machines consisting of tens of thousands of parts and assemblies. Due to special engineering requirements, processes, and materials, the lead time for many of the parts can be several months resulting ...
External operations portfolio analysis and segmentation
(Massachusetts Institute of Technology, 2014)
This thesis focuses on a medical device manufacturer, Company X, using a razor-and-blades business strategy, in which surgical instruments are offered to customers at little or no cost in order to facilitate the sale of ...