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Characterization of self-assembling peptide nanofibers of KLD12 and RID 12

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dc.contributor.advisor Shuguang Zhang. en_US Dai, Jessica, 1981- en_US
dc.contributor.other Massachusetts Institute of Technology. Biological Engineering Division. en_US 2005-06-02T19:45:38Z 2005-06-02T19:45:38Z 2004 en_US 2004 en_US
dc.description Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004. en_US
dc.description Includes bibliographical references (p. 70-72). en_US
dc.description.abstract Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and RID12 and to generate new ways to control the properties of them. Peptide structures in solution were studied with circular dichroism and dynamic light scattering, and material properties of the peptide solutions were studied with rheology. Nanofiber structure was studied through atomic force microscopy. Sonication was found to have a minimal effect on KLD12, while pH could alter the length of the fibers formed. The presence of a second type of peptide in solution interacted with nanofibers of another peptide and resulted in a decrease of average fiber length. Peptide solutions transitioned from a viscous solution to a gel as the concentration of peptide increased, both alone and in mixture with another peptide. Understanding the properties of these peptides will help researchers design new biomaterials and improve applications of self-assembling peptides. en_US
dc.description.statementofresponsibility by Jessica Dai. en_US
dc.format.extent 72 p. en_US
dc.format.extent 2847381 bytes
dc.format.extent 2854875 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. en_US
dc.subject Biological Engineering Division. en_US
dc.title Characterization of self-assembling peptide nanofibers of KLD12 and RID 12 en_US
dc.type Thesis en_US M.Eng. en_US
dc.contributor.department Massachusetts Institute of Technology. Biological Engineering Division. en_US
dc.identifier.oclc 57364247 en_US

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