Browsing Synthetic Biology by Issue Date
Now showing items 21-40 of 139
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Engineered Post-Translational Logic (PTL)
(2005-12-07)Current synthetic biological circuits make use of protein-DNA and RNA-RNA interactions to control gene expression in bacteria. Systems that rely on the regulation of gene expression are relatively slow and unsuitable for ... -
Definitions and Measures of Performance for Standard Biological Parts
(2006-03-16)We are working to enable the engineering of integrated biological systems. Specifically, we would like to be able to build systems using standard parts that, when combined, have reliable and predictable behavior. Here, ... -
A New Biobrick Assembly Strategy Designed for Facile Protein Engineering
(2006-04-20)The existing biobrick assembly technique[1] provides a straightforward way to combine standardized biological components, termed biobricks. This system, however, is limited in that each protein-encoding biobrick must ... -
GeneJax: A Prototype CAD tool in support of Genome Refactoring
(2006-05-26)Refactoring is a technique used by computer scientists for improving program design. The Endy Laboratory has adapted this process to make the genomes of biological organisms more amenable to human understanding and design ... -
May 2006 correspondance between James Randerson and Drew Endy
(2006-06-15)I am a science journalist with the Guardian newspaper in London. We are a national daily paper. I am hoping to put together an investigative piece on how easy (or not) it would be for a would-be terrorist to put together ... -
Power and responsibility
(2006-11-21)Peter Parker and Uncle Ben are on my mind. The reason is that is that a month ago I was jumped by Craig Venter. There were TV cameras around. The live audience was an interesting, edgy mix, on the interface between ... -
In the valley of the shadow of death
(2006-11-22)During the 20th century, advances in biological understanding sparked a global revolution in biological capability, or RBC. Since that time, the revolution has proceeded in a Moore's-law-like fashion for many decades. ... -
Code accompanying "Analysis of Targeted and Combinatorial Approaches to Phage T7 Genome Generation" Master's Thesis
(2006-11-26)Code accompanying "Analysis of Targeted and Combinatorial Approaches to Phage T7 Genome Generation" Master's Thesis. -
A Practical Perspective on DNA Synthesis and Biological Security (12/4/2006 Draft)
(2006-12-12)Few developments have leapfrogged over predecessor technology as quickly and extensively as synthetic biology. Based on cutting-edge DNA synthesis technology, synthetic biology has already fueled an expansion of ... -
Simulation, Models, and Refactoring of Bacteriophage T7
(2007-02-02)Our understanding of why biological systems are designed in a particular way would benefit from biophysically-realistic models that can make accurate predictions on the time-evolution of molecular events given arbitrary ... -
Analysis of Targeted and Combinatorial Approaches to Phage T7 Genome Generation
(2007-02-06)I performed computational analyses of various approaches to generating re- engineered versions of the genome of bacteriophage T7. I analyzed a proposed design for a re-engineered genome by examining conservation of T7 ... -
Draft Standard for Biobrick Biological Parts
(OpenWetWare, 2007-05-03)This standard defines the required sequence properties for a Biobrick(tm) standard biological part. It does not define any functional characteristics of the parts, nor does it motivate any aspect of these standards. ... -
Engineering transcription-based digital logic devices
(2007-07-17)Implementing in vivo information processing is a key challenge in synthetic biology. We describe the construction and characterization of digital transcription-based devices from zinc fingers and leucine zippers. We also ... -
2003 Synthetic Biology study
(2007-08-14)Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable ... -
Registry of BioBricks Models using CellML
(2007-10-04)One of the main goals in Synthetic Biology is to assess the feasibility of building novel biological systems from interchangeable and standardized parts. In order to collect and share parts, a Registry of standardized DNA ... -
Synthetic Genomics: Options for Governance
(2007-10-17)Gene and genome synthesis, that is, constructing long stretches of DNA from constituent chemicals, provides scientists with new and unparalleled capabilities both for understanding biology and for using it for beneficial ... -
Synthetic Viral Genomics: Risks and Benefits for Science and Society
(2007-12-04)Viral disease outbreaks have long inspired fear in human populations. Highly pathogenic infectious disease has shaped world history, primarily by impacting the outcome of wars and other global conflicts and precipitating ... -
Impact of Synthetic Genomics on the Threat of Bioterrorism with Viral Agents
(2007-12-04)In 2002, a team of researchers at the State University of New York led by Eckard Wimmer assembled a DNA template for the RNA poliovirus using an internet-available nucleotide sequence and mail order synthetic ...