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Proposed Conceptual Guidelines for the Design of a BioBrick Graphical Language & an Example
(2009-03-12)
As we update the current BioBrick symbols we have an opportunity to look at the
end users of a BioBrick Graphical language and develop design guidelines so that
the new symbols best suit their needs. This document explores ...
Synthetic Viral Genomics: Risks and Benefits for Science and Society
(2007-12-04)
Viral disease outbreaks have long inspired fear in human populations. Highly pathogenic
infectious disease has shaped world history, primarily by impacting the outcome of wars
and other global conflicts and precipitating ...
Sequence Screening
(2007-12-04)
Currently the vast majority of DNA synthesis is
performed by service companies or by in-house central facilities in universities and large
companies. The DNA synthesis industry provides researchers with custom DNA at ...
A Roadmap to the Assembly of Synthetic DNA from Raw Materials
(2007-12-04)
Until recently, the synthesis of DNA has been a tedious, time consuming, expensive and
experimentally challenging task. But advances in automated instrumentation and
improved chemistry have now made it possible to make ...
BBF RFC 28: A method for combinatorial multi-part assembly based on the Type IIs restriction enzyme AarI
(2009-09-16)
This BioBricks Foundation Request for Comments (BBF RFC) describes an alternative
assembly standard based on the Type IIS restriction enzyme AarI.
Applying engineering principles to the design and construction of transcriptional devices
(2008-05-27)
The aim of this thesis is to consider how fundamental engineering principles might best be applied to the design and construction of engineered biological systems. I begin by applying these principles to a key application ...
A New Biobrick Assembly Strategy Designed for Facile Protein Engineering
(2006-04-20)
The existing biobrick assembly technique[1] provides a straightforward
way to combine standardized biological components, termed biobricks.
This system, however, is limited in that each protein-encoding biobrick
must ...
Fluorescence Assay for Polymerase Arrival Rates
(2003-08-31)
To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
Adventures in Synthetic Biology
(OpenWetWare & Nature Publishing Group, 2005-11-24)