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Analysis of transcriptional regulatory circuitry

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dc.contributor.advisor Richard A. Young. en_US Rinaldi, Nicola J., 1974- en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Biology. en_US 2005-09-27T17:39:37Z 2005-09-27T17:39:37Z 2004 en_US 2004 en_US
dc.description Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract The research in this thesis has focused on the analysis of data from two types of microarray technologies with the goal of improving understanding of transcriptional regulatory circuitry in yeast. These microarray technologies, expression analysis and location analysis (ChIP on CHIP), bring unique challenges for data analysis. I have adapted methods described previously and have developing new algorithms for addressing some of these challenges. I generated yeast transcription factor location data as part of a team effort to determine how a large set of transcriptional regulators occupy the yeast genome and to facilitate discovery of regulatory network structures. I also contributed to another team effort to deduce a portion of the yeast transcriptional regulatory code, the set of genomic DNA sequences recognized by transcriptional regulators to effect gene expression programs. Finally, I used these experimental and analytical methods to explore changes in gene expression circuitry that occur after exposure to oxidative stress in yeast. en_US
dc.description.statementofresponsibility by Nicola J. Rinaldi. en_US
dc.format.extent 195 leaves en_US
dc.format.extent 10067993 bytes
dc.format.extent 10092615 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Biology. en_US
dc.title Analysis of transcriptional regulatory circuitry en_US
dc.type Thesis en_US Ph.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Biology. en_US
dc.identifier.oclc 58994970 en_US

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