Show simple item record

dc.contributor.advisorRichard A. Young.en_US
dc.contributor.authorRinaldi, Nicola J., 1974-en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Biology.en_US
dc.date.accessioned2005-09-27T17:39:37Z
dc.date.available2005-09-27T17:39:37Z
dc.date.copyright2004en_US
dc.date.issued2004en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/28674
dc.descriptionThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.description.abstractThe research in this thesis has focused on the analysis of data from two types of microarray technologies with the goal of improving understanding of transcriptional regulatory circuitry in yeast. These microarray technologies, expression analysis and location analysis (ChIP on CHIP), bring unique challenges for data analysis. I have adapted methods described previously and have developing new algorithms for addressing some of these challenges. I generated yeast transcription factor location data as part of a team effort to determine how a large set of transcriptional regulators occupy the yeast genome and to facilitate discovery of regulatory network structures. I also contributed to another team effort to deduce a portion of the yeast transcriptional regulatory code, the set of genomic DNA sequences recognized by transcriptional regulators to effect gene expression programs. Finally, I used these experimental and analytical methods to explore changes in gene expression circuitry that occur after exposure to oxidative stress in yeast.en_US
dc.description.statementofresponsibilityby Nicola J. Rinaldi.en_US
dc.format.extent195 leavesen_US
dc.format.extent10067993 bytes
dc.format.extent10092615 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectBiology.en_US
dc.titleAnalysis of transcriptional regulatory circuitryen_US
dc.typeThesisen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biology
dc.identifier.oclc58994970en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record