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Early diagnosis of cancer using light scattering spectroscopy

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dc.contributor.advisor Michael S. Feld and Lev T. Perelman. en_US Backman, Vadim, 1973- en_US
dc.contributor.other Harvard University--MIT Division of Health Sciences and Technology. en_US 2006-03-24T18:00:38Z 2006-03-24T18:00:38Z 2001 en_US 2001 en_US
dc.description Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2001. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract This thesis presents a novel optical technique, light scattering spectroscopy (LSS), developed for quantitative characterization of tissue morphology as well as in vivo detection and diagnosis of the diseases associated with alteration of normal tissue structure such as precancerous and early cancerous transformations in various epithelia. LSS employs a wavelength dependent component of light scattered by epithelial cells to obtain information about subcellular structures, such as cell nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs, which can be optically accessed either directly or by means of optical fibers. We have developed several types of LSS instrumentation including 1) endoscopically compatible LSS-based fiber-optic system; en_US
dc.description.abstract (cont.) 2) LSS-based imaging instrumentation, which allows mapping quantitative parameters characterizing nuclear properties over wide, several cm2, areas of epithelial lining; and 3) scattering angle sensitive LSS instrumentation (a/LSS), which enables to study the internal structure of cells and their organelles, i.e. nuclei, on a submicron scale. Multipatient clinical studies conducted to test the diagnostic potential of LSS in five organs (esophagus, colon, bladder, cervix and oral cavity) have shown the generality and efficacy of the technique and indicated that LSS may become an important tool for early cancer detection as well as better biological understanding of the disease. en_US
dc.description.statementofresponsibility by Vadim Backman. en_US
dc.format.extent 256 leaves en_US
dc.format.extent 13741957 bytes
dc.format.extent 13776084 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Harvard University--MIT Division of Health Sciences and Technology. en_US
dc.title Early diagnosis of cancer using light scattering spectroscopy en_US
dc.title.alternative Early diagnosis of cancer using LSS en_US
dc.type Thesis en_US Ph.D. en_US
dc.contributor.department Harvard University--MIT Division of Health Sciences and Technology. en_US
dc.identifier.oclc 49545131 en_US

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