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Nanoscale properties of poly(ethylene terephthalate) vascular grafts

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dc.contributor.advisor Christine Ortiz. en_US
dc.contributor.author Macias, Celia Edith, 1982- en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. en_US
dc.date.accessioned 2006-05-15T20:25:45Z
dc.date.available 2006-05-15T20:25:45Z
dc.date.copyright 2004 en_US
dc.date.issued 2004 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/32727
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2004. en_US
dc.description Includes bibliographical references (leaves 46-48). en_US
dc.description.abstract Vascular grafts are prosthetic tubes that serve as artificial replacements for damaged blood vessels. Poly(ethylene-terephthalate), PET, has been successfully used in large diameter grafts; however, small caliber grafts are still a major challenge in biomaterials. Due to surface forces, blood plasma proteins adsorb to the graft, resulting in inflammation, infection, thrombus formation, and ultimately, vessel reclosure. The object of this project was to characterize and analyze the nanoscale surface properties of three different commercial vascular grafts, woven collagen-coated, knitted collagen- coated, and knitted heparin-bonded, all PET-based. The study was performed in order to ascertain differences in biocompatibility due to surface coating and morphology. Scanning Electron Microscopy, Atomic Force Microscopy and High Resolution Force Spectroscopy techniques were used to characterize the surface of the samples as well as to measure the forces between these surfaces and blood plasma proteins. The results will serve as a basis for the understanding of the nanoscale interactions between the biomaterial and blood plasma proteins. Such interactions are brought about by the different surface topologies and components, therefore a thorough understanding of surface properties will act as a building block for further changes in small caliber vascular grafts in order to enhance their biocompatibility. en_US
dc.description.statementofresponsibility by Celia Edith Macias. en_US
dc.format.extent 48 leaves en_US
dc.format.extent 2843923 bytes
dc.format.extent 2844240 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582
dc.subject Materials Science and Engineering. en_US
dc.title Nanoscale properties of poly(ethylene terephthalate) vascular grafts en_US
dc.type Thesis en_US
dc.description.degree S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. en_US
dc.identifier.oclc 56518293 en_US


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