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Ca2+ dependant synaptic modification

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dc.contributor.advisor Guosong Liu. en_US Huh, Dongsung, 1981- en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US 2006-05-15T20:26:43Z 2006-05-15T20:26:43Z 2004 en_US 2004 en_US
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics; and, (S.B.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2004. en_US
dc.description Includes bibliographical references (p. 21-22). en_US
dc.description.abstract It has been assumed that Ca2+ influx of different duration and amplitude would generate different level of potentiation. The conventional protocols of generating LTP have been 1. tetanic stimulation of presynaptic cell, 2. theta burst stimulation of presynaptic cell, and 3. correlated stimulation of pre- and post-synaptic cells. However, the effects of different Ca2+ influx can not be precisely dissected with the conventional protocols for the following defects: 1. the protocols do not discriminate between pre- and post-synaptic side plasticity, 2. the protocols observe synaptic plasticity between two cells which involve multiple synapses with heterogeneous properties, 3. precise control and measurement of the amount of Ca2+ influx are not possible in the protocols. In the present experiment, we perfused glutamate directly on to a single postsynaptic site, depolarized the postsynaptic intracellular potential to a controlled voltage for a controlled duration of time, thus controlling the opening of postsynaptic NMDA receptors and Ca2+ influx. By using this method, we found 1. that modification of synaptic strength has a bell-shaped dependency to the amount of Ca2+ influx, 2. that weak Ca2+ current through desensitized NMDA receptors sustained for a long period of time (160 ms) generates LTD, 3. evidence that phosphorylation of AMPAR leads to insertion of AMPAR. en_US
dc.description.statementofresponsibility by Dongsung Huh. en_US
dc.format.extent 44 p. en_US
dc.format.extent 2500300 bytes
dc.format.extent 2500382 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Physics. en_US
dc.subject Brain and Cognitive Sciences. en_US
dc.title Ca2+ dependant synaptic modification en_US
dc.type Thesis en_US S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Physics. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.identifier.oclc 56730254 en_US

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