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Nano-contact printing of DNA monolayers

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dc.contributor.advisor Francesco Stellacci. en_US
dc.contributor.author Tong, Angela, 1983- en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. en_US
dc.date.accessioned 2006-05-15T20:34:58Z
dc.date.available 2006-05-15T20:34:58Z
dc.date.copyright 2005 en_US
dc.date.issued 2005 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/32856
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005. en_US
dc.description Includes bibliographical references (leaf 23). en_US
dc.description.abstract Technology today is directed towards building smaller devices. To accommodate this development, printing methods are needed. Some printing methods that are used include lithography, micro-contact printing, and inkjet printing. These methods all require specialized instrumentation, hazardous chemicals, and complicated and tedious steps that increase cost of manufacturing. Nano-contact printing is an alternative solution which relies on the specificity of DNA to direct molecules into precise patterns. This study attempts to find the limitations of nano-contact printing through the printing of oligonucleotide monolayers. Eight pattern transfers were made with one master copy and the oligonucleotide surface coverage was analyzed using tapping mode atomic force microscopy (AFM). The percent coverage of oligonucleotide was then calculated from the tapping mode AFM phase images. Two general trends were found. The oligonucleotide surface coverage on the master increased slightly, while the surface coverage on the pattern transfers decreased. One possible explanation for the trends is that the decrease in contact between master and secondary substrate is due to both the accumulation of dirt and the wear and tear of' the master. By improving the contact between master and secondary substrate, the printing method can be expanded from printing monolayers to high resolution patterns. en_US
dc.description.statementofresponsibility by Angela Tong. en_US
dc.format.extent 23 leaves en_US
dc.format.extent 991795 bytes
dc.format.extent 989950 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582
dc.subject Materials Science and Engineering. en_US
dc.title Nano-contact printing of DNA monolayers en_US
dc.title.alternative Nano-contact printing of deoxyribonucleic acid monolayers en_US
dc.type Thesis en_US
dc.description.degree S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. en_US
dc.identifier.oclc 61490376 en_US


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