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Multiple spatial memories in the brain : decoding and modification using microstimulation

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dc.contributor.advisor Earl K. Miller. en_US Histed, Mark H en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US 2006-06-20T12:53:34Z 2006-06-20T12:53:34Z 2005 en_US 2005 en_US
dc.description Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2005. en_US
dc.description This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections. en_US
dc.description Includes bibliographical references (leaves 87-97). en_US
dc.description.abstract Sequential processing --- using multiple sensory stimuli to plan and control a set of ordered movements --- is a central aspect of human behavior. Because previous and future movements must be stored during the execution of any movement in a sequence, memory is an indispensable aspect of sequential behavior. To study how memory is used to link sensory inputs to sequential motor outputs, we have used the oculomotor system as a model. We trained monkeys to remember the location of two spatial cues over a brief delay, and then make two eye movements to the remembered locations in the order that they appeared. We explored the role of two different frontal eye movement areas, the frontal and supplementary eye fields (FEF and SEF) during this memory delay. While both the FEF and SEF have shown to be important for sequential behavior, their individual roles are unknown. Here, using physiology, we show that the FEF is important for storing the location of multiple cues and their order in memory. In the SEF, we show that memory period stimulation can affect the order of a sequence, changing the goal of the entire sequence but not the individual movement components. en_US
dc.description.abstract (cont.) Thus, both areas appear to play complementary roles in sequential planning: the FEF stores target locations, while the SEF appears to control the order of a response sequence, coding entire sequences without affecting the locations of the intermediate targets. This work bears on several outstanding questions in the field. It clarifies the individual roles of the FEF and SEF during sequencing: the FEF may serve as a buffer for multiple memories while the SEF plays a role in organizing movement sequences. It relates several prior SEF results, suggesting that a primary role of SEF may be to specify movements by their goal. Finally, we suggest that this goal-centered scheme may be a fundamental way that many different types of movements are encoded. en_US
dc.description.statementofresponsibility by Hark H. Histed. en_US
dc.format.extent 97 leaves en_US
dc.format.extent 1510235 bytes
dc.format.extent 1508087 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Brain and Cognitive Sciences. en_US
dc.title Multiple spatial memories in the brain : decoding and modification using microstimulation en_US
dc.type Thesis en_US Sc.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.identifier.oclc 65170645 en_US

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