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Needle-free drug delivery using shock wave techniques

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dc.contributor.advisor Ian W. Hunter. en_US Pavlov, Atanas (Atanas Ivanov) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US 2007-02-21T13:14:00Z 2007-02-21T13:14:00Z 2006 en_US
dc.description Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006. en_US
dc.description "June 2006." en_US
dc.description Includes bibliographical references (leaves 93-94). en_US
dc.description.abstract A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug particles 2 to 50 gpm in size to velocities of 200 to 1000 m/s. At these speeds the particles have sufficient momentum to penetrate the skin barrier and reach the viable epidermal layers. The devices offer much better control over the depth of penetration than traditional hypodermic needles, a factor particularly important in vaccine delivery. However they still have not found wide spread use, because of their cost. We studied the parameters determining the performance of these devices and used that knowledge to create a simple and reusable device capable of delivering 3 to 10 mg of powder formulation to the viable epidermis. Furthermore we showed that hydrogen-oxygen combustion could be used to create the shock wave required to accelerate the drug particles. This proves that portable reusable devices powered by hydrogen can be constructed and used for vaccine and medication delivery. en_US
dc.description.statementofresponsibility by Atanas Pavlov. en_US
dc.format.extent 94 leaves en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Mechanical Engineering. en_US
dc.title Needle-free drug delivery using shock wave techniques en_US
dc.type Thesis en_US S.M. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.identifier.oclc 77274870 en_US

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