Advances in palladium-catalyzed carbon-nitrogen bond forming processes
Citable URI:
http://hdl.handle.net/1721.1/36283
| Title: | Advances in palladium-catalyzed carbon-nitrogen bond forming processes |
| Author: | Tundel, Rachel E. (Rachel Elizabeth) |
| Other Contributors: | Massachusetts Institute of Technology. Dept. of Chemistry. |
| Advisor: | Stephen L. Buchwald. |
| Department: | Massachusetts Institute of Technology. Dept. of Chemistry. |
| Publisher: | Massachusetts Institute of Technology |
| Issue Date: | 2006 |
| Abstract: | Chapter 1. Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates/halides and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and a catalyst system consisting of Pd2dba3 and ligands (XantPhos, 2-dicylcohexylphosphino-2',4',6'-triisopropyl-1,1 '-biphenyl (XPhos) and 2-di-tert-butylphosphino-2',4',6'-triisopropyl-1, '-biphenyl) resulted in good to excellent yields of arylamines in short reaction times. Chapter 2. Using a catalyst comprised of the bulky, electron-rich monophosphine ligand di-tert-Butyl XPhos (2-di-tert-butylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl) and Pd2dba3 with sodium tert-butoxide as the base, amino heterocycles were coupled successfully with aryl/heteroaryl halides in moderate to excellent yields. |
| Description: |
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006. Vita. Leaf 68 blank. Includes bibliographical references. |
| URI: | http://hdl.handle.net/1721.1/36283 |
| Keywords: | Chemistry. |
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