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Title:
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NIR-Sensitive Au-Au₂S Nanoparticles for Drug Delivery |
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Author:
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Ren, L.; Chow, Gan-Moog |
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Issue Date:
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2003-01 |
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Abstract:
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Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au₂S nanoparticles was controlled by the pH value of solution, and the drug release was sensitive to NIR irradiation. The cis-platin loaded Au-Au₂S nanoparticles can be potentially applied as NIR activated drug delivery carrier. |
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URI:
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http://hdl.handle.net/1721.1/3787
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Series/Report no.:
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Molecular Engineering of Biological and Chemical Systems (MEBCS); |
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Keywords:
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drug delivery, near-infrared, Au-Au2, nanoparticles, cis-Platin |
