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Characterizing the modulation of mGluR5 in a 6-OHDA-induced rat model of Parkinson's disease

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dc.contributor.advisor Anna-Liisa Brownell and David Cory. en_US
dc.contributor.author Lamb, Peter (Peter Alexander John) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Nuclear Science and Engineering. en_US
dc.date.accessioned 2009-03-16T19:49:37Z
dc.date.available 2009-03-16T19:49:37Z
dc.date.copyright 2008 en_US
dc.date.issued 2008 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/44840
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2008. en_US
dc.description Includes bibliographical references (leaves 26-27). en_US
dc.description.abstract MicroPET imaging studies were conducted to investigate the role of metabotropic glutamate subtype-5 receptors (mGluR5) in Parkinson's disease (PD). Four analogical PET ligands were used to characterize modulation of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral 6-OHDA lesions were made in the right medial forebrain bundle, and severity of these lesions was determined with [¹¹]CFT. The binding characteristics of the PET ligands were analyzed using a modified distribution volume method of the Logan reference region model. Binding potential values were calculated on the striatum, hippocampus, and cortex, using the cerebellum as a reference tissue. On the right (with lesion) side of the striatum, ["C]CFT binding decreased. Three of the four investigated mGluR5 ligands ([¹¹C]MPEP, [¹¹C]M-PEPy, and [¹¹C]MMPEP) also showed enhanced binding characteristics on the same side of the brain. The right hippocampus and cortex showed similar results. The mGluR5s' enhanced binding characteristics on the right side of the brain suggest a complementary and compensatory role of metabotropic glutamate receptors in the dopaminergic neurodegeneration of Parkinson's disease. en_US
dc.description.statementofresponsibility by Peter Lamb. en_US
dc.format.extent 27 leaves en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Nuclear Science and Engineering. en_US
dc.title Characterizing the modulation of mGluR5 in a 6-OHDA-induced rat model of Parkinson's disease en_US
dc.type Thesis en_US
dc.description.degree S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Nuclear Science and Engineering. en_US
dc.identifier.oclc 301587846 en_US


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