MIT Open Access Articles

Controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes

Pires, Ivan S; Ni, Kaiyuan; Melo, Mariane Bandeira; Li, Na; Ben-Akiva, Elana; e.a. (Elsevier BV, 2023-05-15)

Immune stimulating complexes (ISCOMs) are safe and effective saponin-based adjuvants formed by the self-assembly of saponin, cholesterol, and phospholipids in water to form cage-like 30-40 nm diameter particles. Inclusion ...
Engineering a Two‐Component Hemostat for the Treatment of Internal Bleeding through Wound‐Targeted Crosslinking

Hong, Celestine; He, Yanpu; Bowen, Porter A; Belcher, Angela M; Olsen, Bradley D; e.a. (Wiley, 2023-04-05)

Primary hemostasis (platelet plug formation) and secondary hemostasis (fibrin clot formation) are intertwined processes that occur upon vascular injury. Researchers have sought to target wounds by leveraging cues specific ...
Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells

Berger, Adam G; Deiss-Yehiely, Elad; Vo, Chau; McCoy, Michael G; Almofty, Sarah; e.a. (Elsevier BV, 2023-09)

Chronic non-healing wounds occur frequently in individuals affected by diabetes, yet standard-of-care treatment leaves many patients inadequately treated or with recurring wounds. MicroRNA (miR) expression is dysregulated ...