MIT Open Access Articles

Host–Guest Complexation by β-Cyclodextrin Enhances the Solubility of an Esterified Protein

Cheah, Keith M; Jun, Joomyung V; Wittrup, K Dane; Raines, Ronald T (American Chemical Society, 2022-08-29)

The carboxyl groups of a protein can be esterified by reaction with a diazo compound, 2-diazo-2-(p-methylphenyl)-N,N-dimethylacetamide. This esterification enables the entry of the protein into the cytosol of a mammalian ...
Quantifying the Role of Kinematic and Behavioral Features in Driver-Pedestrian Interaction across Environments: An Inverse Reinforcement Learning Approach

Noonan, T Zach; Gershon, Pnina; Domeyer, Josh; Mehler, Bruce; Reimer, Bryan (SAGE Publications, 2025-09)

This study examined real-world driver-pedestrian encounters to identify key interaction features and assess how the importance of these features is mediated by protection afforded by the environment. Using inverse reinforcement ...
Preoperative Function, Previous SERM Treatment, and Triple-Negative Tumor Status are Independently Associated With 3-Month Postoperative Function After Surgical Decompression of Metastatic Breast Cancer

Siraj, Layla; Duvall, Julia B.; Massaad, Elie; Fourman, Mitchell S.; Shin, John H. (SAGE Publications, 2025-11-04)

Background: The most common cancer in women worldwide, breast cancer most often metastasizes to the bone. Improved chemo- and radiotherapies and novel molecular therapies have prolonged survival in women with osseous ...