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Computational and Systems Biology

Research and Teaching Output of the MIT Community

Computational and Systems Biology


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Recent Submissions

  • Negron, Christopher (Massachusetts Institute of Technology, 2014)
    Living cells integrate a vast array of protein-protein interactions (PPIs) to govern cellular functions. For instance, PPIs are critical to biosynthesis, nanostructural assembly, and in processing environmental stimuli ...
  • Al-Obeidi, Arshed (Massachusetts Institute of Technology, 2014)
    Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the ...
  • Adadey, Asa (Asa Owuraku) (Massachusetts Institute of Technology, 2014)
    Alternative splicing of mRNA transcripts is a significant step in the production of functioning protein. This process is a major source of molecular diversity, as numerous mRNA and protein products can arise from a single ...
  • Wu, Xuebing, Ph. D. Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2014)
    The vast majority of the mammalian genome does not encode proteins. Only 2% of the genome is exonic, yet recent deep survey of human transcripitome suggested that 75% of the genome is transcribed, including half of the ...
  • Podgornaia, Anna Igorevna (Massachusetts Institute of Technology, 2014)
    Signal transduction pathways rely on transient yet specific protein-protein interactions. How a limited set of amino acids can enforce cognate protein interactions while excluding undesired pairings remains poorly understood, ...