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Roles for chromatin regulators during differentiation of embryonic stem cells

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dc.contributor.advisor Richard A. Young. en_US Whyte, Warren A. (Warren Anthony) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Biology. en_US 2012-09-13T18:53:56Z 2012-09-13T18:53:56Z 2012 en_US 2012 en_US
dc.description Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract Mammalian development involves the process by which a single fertilized egg develops into an adult with over 200 specialized cell types, each with a distinct gene expression pattern controlling its cellular state. As cells differentiate into specialized cell types, changes in the gene expression program occur with associated changes in chromatin. An understanding of the roles for chromatin regulators in the control of gene expression programs during differentiation is fundamental to understanding development. Although it is not yet feasible to elucidate the functions of all chromatin regulators in all vertebrate cells, recent work in embryonic stem (ES) cells has demonstrated that regulatory features of differentiation can be elucidated by focusing on the chromatin regulators involved in the changes in the pluripotent gene expression program as ES cells differentiate. New insights reveal that chromatin regulators of opposing functions share a common set of active genes in ES cells, suggesting a dynamic balance in the control of embryonic stem cell state and differentiation. I describe here the molecular mechanisms by which chromatin regulators contribute to the control of the ES cell state and differentiation, where these regulators play critical roles both in activating new gene expression programs and in silencing old programs. en_US
dc.description.statementofresponsibility by Warren A. Whyte. en_US
dc.format.extent 278 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri en_US
dc.subject Biology. en_US
dc.title Roles for chromatin regulators during differentiation of embryonic stem cells en_US
dc.type Thesis en_US Ph.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Biology. en_US
dc.identifier.oclc 806952865 en_US

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