Browsing MIT Theses by Title
Now showing items 50933-50952 of 61728
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Single molecule detection and classification using nanogaps
(Massachusetts Institute of Technology, 2021)Finding life beyond Earth has been a major focus of space exploration since the dawn of the space age. There have been a number of instruments developed for the purposes of life detection, but there are lmited options for ... -
Single molecule DNA dynamics in micro- and nano-fluidic devices
(Massachusetts Institute of Technology, 2011)Rapid genome characterization is one of the grand challenges of genome science today. Although the complete sequences of certain representative human genomes have been determined, genomes from a much larger number of ... -
Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation
(Massachusetts Institute of Technology, 2009)Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in prokaryotes and organelles of eukaryotes. AAA+ ATPases in these proteases recognize protein substrates and power their ... -
Single molecule techniques to probe decision-making processes in developmental biology
(Massachusetts Institute of Technology, 2014)This work investigates the fundamental processes used by mammalian cells and organisms to make decisions during embryonic development. Current technologies that evaluate biological phenomenon often force a compromise between ... -
Single nanocrystal spectroscopy of near and shortwave infrared emitters
(Massachusetts Institute of Technology, 2019)Optimizing material systems for their translation to the marketplace relies on a complete understanding of the underlying fundamental physical mechanisms governing the observed properties of the material. In semiconducting ... -
Single particle spectrum of the two dimensional electron gas
(Massachusetts Institute of Technology, 2007)Accurate spectroscopy has driven advances in chemistry, materials science, and physics. However, despite their importance in the study of highly correlated systems, two-dimensional systems (2DES) have proven difficult to ... -
Single particle, high temperature, gas-solid reactions in an electrodynamic balance
(Massachusetts Institute of Technology, 1988) -
Single property commercial mortgage-backed securities : an analysis of the covenants
(Massachusetts Institute of Technology, 1994) -
Single Subcompartment Drug Delivery
(Massachusetts Institute of Technology, 2021-06)Most drugs are administered systemically, intravenously or orally, but there are inherent challenges with these methods. Drug distributes throughout the body, which results in two main challenges: (1) poor efficacy due to ... -
A single supply wide bandwidth 4:1 video multiplexer in an 8 GHz dielectrically isolated complementary bipolar process
(Massachusetts Institute of Technology, 1998) -
Single Transponder Range Only Navigation Geometry (STRONG) applied to REMUS autonomous under water vehicles
(Massachusetts Institute of Technology, 2005)A detailed study was conducted to prove the concept of an iterative approach to single transponder navigation for REMUS Autonomous Underwater Vehicles (AUVs). Although the concept of navigation with one acoustic beacon is ... -
Single- and few-layer graphene by ambient pressure chemical vapor deposition on nickel
(Massachusetts Institute of Technology, 2010)An ambient pressure chemical vapor deposition (APCVD) process is used to fabricate graphene based films consisting of one to several graphene layers across their area. Polycrystalline Ni thin films are used and the graphene ... -
Single-cell analyses of cellular reprogramming and embryonic stem cells
(Massachusetts Institute of Technology, 2014)Three years before the start of this thesis, Yamanaka and Takahashi published a groundbreaking paper entitled "Induced of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." A ... -
Single-cell analyses of tumor-infiltrating immune cells
(Massachusetts Institute of Technology, 2018)Immunotherapies and targeted therapies are emerging as promising methods of treating cancer, with high response rates and low associated side effects when compared with more traditional methods of cancer treatment. Across ... -
Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals
(Massachusetts Institute of Technology, 2022-09)Alzheimer’s Disease (AD) is a polygenic disease with variable phenotypic response among patients. While single-cell differential expression data can provide important information regarding the disease’s pathology, it only ... -
Single-cell mass measurements for drug susceptibility testing in cancer
(Massachusetts Institute of Technology, 2020)Measuring the size distributions of micron-scale particles is of central importance in the biological sciences and for a wide range of industrial processes. The suspended microchannel resonator (SMR) is a sensor that ... -
Single-cell methods for profiling tumor & microenvironment responses to therapeutic challenges
(Massachusetts Institute of Technology, 2020)Heterogeneity among cells affects function and dysfunction across many complex biological systems. This heterogeneity is particularly important in cancer biology, where variation in the cells composing tumors and their ... -
Single-cell morphological data reveals signaling network architecture
(Massachusetts Institute of Technology, 2010)Metastasis, the migration of cancer cells from the primary site of tumorigenesis and the subsequent invasion of secondary tissues, causes the vast majority of cancer deaths. To spread, metastatic cells dramatically rearrange ... -
A single-cell perspective on infection
(Massachusetts Institute of Technology, 2016)The clinical course of infection is ultimately determined by a series of cellular interactions between invading pathogens and host immune cells. It has long been understood that these interactions, even when they occur in ... -
Single-cell reporters for inflammatory caspase activity
(Massachusetts Institute of Technology, 2014)Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the ...
