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Now showing items 141-150 of 191
Cost modeling for monoclonal antibody manufacturing
(Massachusetts Institute of Technology, 2011)
The Novartis BioPharmOps division is responsible for manufacturing large molecule products, including monoclonal antibodies, for late stage clinical trials and commercial sales. The BioPharmOps site in Huningue, France is ...
Connected factory: real time data analysis for manufacturing efficiency
(Massachusetts Institute of Technology, 2020)
Pratt and Whitney is expecting an increase in demand for new engines and for parts supportive of aftermarket service, maintenance, and repair. To avoid expensive capital investments in additional production capacity, Pratt ...
Applications of risk pooling for the optimization of spare parts with stochastic demand within large scale networks
(Massachusetts Institute of Technology, 2020)
Amazon is able to deliver millions of packages to customers every day through its Fulfillment Center (FC) network that is powered by miles of material handling equipment (MHE) such as conveyor belts. Unfortunately, this ...
Improving operational effectiveness in the job-shop environment through discrete event simulation and innovative process design
(Massachusetts Institute of Technology, 2018)
A key value stream for Company X is a manufacturing area dedicated to production of precision electro-mechanical systems, of which they are contracted to service during the complete lifecycle. Currently, the production ...
Modeling the effects of advanced automation and process design on Cell Line Development
(Massachusetts Institute of Technology, 2015)
Research and development of biologic drugs is a time- and resource-intensive process that can span several years and billions of dollars. Any improvements in the efficiency and end-to-end cycle time of this process provide ...
Improving surgical patient flow in a congested recovery area
(Massachusetts Institute of Technology, 2012)
The recent movement in healthcare reform requires hospitals to care for more patients while simultaneously reducing costs. Medical institutions can no longer afford to simply add beds and hire staff to increase capacity. ...
Improving shop floor visualization and metrics
(Massachusetts Institute of Technology, 2010)
Within the Technical Operations division of Novartis Pharmaceuticals, there is an aggressive vision to be the "Toyota" of the Pharma Industry by 2010. To accomplish this, PharmOps Switzerland has embraced operational ...
Crisplant defects quantification and reduction at an amazon.com distribution center
(Massachusetts Institute of Technology, 2010)
Crisplant is a tilt-tray sortation system used in Reno (RNO 1) fulfillment center (FC) to group items by customer orders. On average., crisplant processes about 80% of the total outbound volume through its multipart operation ...
Development of alternate parts for the aerospace industry
(Massachusetts Institute of Technology, 2010)
This thesis explores the topic of the development of alternate parts for the aerospace industry, drawing on industry examples to demonstrate methods and approaches and the benefits to firms engaged in these activities. I ...
Using discrete-event simulation to increase system capacity : a case study of an assembly plant
(Massachusetts Institute of Technology, 2020)
As part of its effort to introduce new technology and to improve the manufacturing system for the 777X production line, Boeing has made a significant capital investment in the Composite Wing Center (CWC). The new facility ...