Del Vecchio, Domitilla
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Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action - Extended Version
(2024-03-21)In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory element leads to increased (rather than decreased) ... -
Error Bound for Hill-Function Approximations in a Class of Stochastic Transcriptional Network Models
(2023-04-01)Hill functions are often used in stochastic models of gene regulation to approximate the dependence of gene activity on the concentration of the transcription factor which regulates the gene. It is incompletely known, ... -
Robust model invalidation for chemical reaction networks using generalized moments (extended version)
(2023-03-31)Many biomolecular systems can be described by chemical reaction networks. Determining which chemical reaction network models are inconsistent with observed data can be done via model invalidation. In this work, we formulate ...
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